Journal
TETRAHEDRON LETTERS
Volume 53, Issue 18, Pages 2308-2311Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.02.096
Keywords
Palladium catalysis; Tetrahydroquinoline; Heck reaction; Suzuki coupling
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A method for the diastereoselective synthesis of tetrahydroquinolines via a palladium-catalyzed Suzuki terminated Heck reaction is described. The reaction provides access to tetrahydroquinolines containing both quaternary and tertiary stereocenters. Ligand effects, a rationale for the high level of diastereoselectivity, and a mechanistic hypothesis are discussed. (C) 2012 Elsevier Ltd. All rights reserved.
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