Journal
TETRAHEDRON LETTERS
Volume 53, Issue 41, Pages 5503-5506Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.07.134
Keywords
Trifluoromethylation; Copper; Olefin; Alkyne; Togni reagent
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Funding
- MEXT [23750116]
- RIKEN
- Grants-in-Aid for Scientific Research [23750116] Funding Source: KAKEN
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Oxytrifluoromethylation reaction of styrene derivatives and alkynes with external and internal oxygen nucleophiles, catalyzed by copper (1) salts under mild conditions, was developed. Direct formation of a beta-trifluoromethylstyrene derivative from a styrene derivative was also achieved by the reaction in the presence of a Bronsted acid. Further transformation of the oxytrifluoromethylated products was conducted to demonstrate their utility. (C) 2012 Elsevier Ltd. All rights reserved.
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