4.4 Article

Directed diversity-oriented synthesis. Ring-fused 5-to 10-membered rings from a common peptidomimetic 2-pyridone precursor

Journal

TETRAHEDRON LETTERS
Volume 53, Issue 45, Pages 6022-6024

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.08.100

Keywords

Diversity-oriented synthesis; Medium-sized rings; Peptidomimetics; 2-Pyridone

Funding

  1. Swedish Natural Research Council [621-2010-4730]
  2. Knut and Alice Wallenberg Foundation
  3. JC Kempe Foundation (SJCKMS)

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A variety of ring-fused 2-pyridone-based central fragments were prepared using a strategy inspired by diversity-oriented synthesis. The produced compounds are diverse, yet focused, analogs of biologically active peptidomimetic 2-pyridones. (C) 2012 Elsevier Ltd. All rights reserved.

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