Journal
TETRAHEDRON LETTERS
Volume 53, Issue 27, Pages 3437-3439Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.04.072
Keywords
Cyclopropanation; Asymmetric catalysis; Chiral nickel catalysts; Nitroalkenes; Conjugate addition
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Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2011-0002488]
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A novel one-pot methodology for the catalytic enantioselective synthesis of highly functionalized nitrocyclopropanes promoted by chiral nickel complexes is developed. The treatment of bromomalonates with nitroalkenes under the mild reaction conditions afforded the corresponding Michael adducts which cyclizes to controlled reaction conditions with excellent diasteroselectivities (>99 de) and enantioselectivities (up to 99% ee). (C) 2012 Elsevier Ltd. All rights reserved.
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