4.4 Article

First stereoselective total synthesis of helicascolides A and C

Journal

TETRAHEDRON LETTERS
Volume 53, Issue 37, Pages 4997-4999

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.07.018

Keywords

Helicascolides A and C; delta-Lactone; 1,3-Syn-diol; Rychnovsky's analogy; Intramolecular lactonization

Funding

  1. CSIR, New Delhi

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The first total synthesis of helicascolides A and C is reported via acid catalyzed acetonide deprotection followed by intramolecular lactonization in one-pot as the key step. (C) 2012 Elsevier Ltd. All rights reserved.

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