4.4 Article

Efficient propylphosphonic anhydride (®T3P) mediated synthesis of benzothiazoles, benzoxazoles and benzimidazoles

Journal

TETRAHEDRON LETTERS
Volume 53, Issue 19, Pages 2440-2443

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.03.007

Keywords

Benzothiazole; Benzoxazole; Benzimidazole; Propylphosphonic anhydride ((R) T3P); Benzazole; Microwave

Funding

  1. National Natural Science Foundation of China [21002125]
  2. China Scholarship Council
  3. la Fondation Franco-Chinoise pour la Science et ses Applications

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Propylphosphonic anhydride ((R) T3P) promotes cyclization of o-aminobenzenethiol, o-aminophenol, and o-phenylenediamine with carboxylic acids under microwave irradiation. The one-pot procedure is efficient and allows short reaction times, easy workup, and good yields. Thus, we describe here a method for quick preparation of benzothiazoles, benzoxazoles and benzimidazoles. (C) 2012 Elsevier Ltd. All rights reserved.

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