Journal
TETRAHEDRON LETTERS
Volume 53, Issue 7, Pages 863-867Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.12.023
Keywords
2,3-Dihydroquinazolin-4(1H)-ones, Aldehydes; Amberlyst-15
Categories
Funding
- Institute of Life Sciences
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An efficient and clean method has been developed for the synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones using Amberlyst-15 as a recyclable catalyst. A variety of dihydroquinazolinones were prepared from 2-aminobenzamide and aldehydes under mild conditions in excellent yields. Further structure elaboration of one compound and the crystal structure analysis and hydrogen bonding patterns of the two compounds prepared by using this methodology is presented. (C) 2011 Elsevier Ltd. All rights reserved.
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