4.4 Article

Aspergilazine A, a diketopiperazine dimer with a rare N-1 to C-6 linkage, from a marine-derived fungus Aspergillus taichungensis

Journal

TETRAHEDRON LETTERS
Volume 53, Issue 21, Pages 2615-2617

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.03.043

Keywords

Aspergilazine A; Diketopiperazine dimer; Aspergillus taichungensis; Antiviral activity

Funding

  1. Chinese National Science Fund [30973627]
  2. Shandong Provincial Natural Science Fund [ZR2009CZ016]
  3. State Oceanic Administration [2010418022-3]
  4. Program for Changjiang Scholars and Innovative Research Team in University [IRT0944]

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A novel diketopiperazine (DKP) dimer, aspergilazine A (1), dimerized by two DKP units via a rare N-1 to C-6 linkage, was isolated from the marine-derived fungus Aspergillus taichungensis ZHN-7-07. The structure was determined by the combination of spectroscopic and Marfey's methods. Biological evaluation indicated that aspergilazine A (1) had a weak activity against influenza A (H1N1) virus. (C) 2012 Elsevier Ltd. All rights reserved.

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