Journal
TETRAHEDRON LETTERS
Volume 53, Issue 21, Pages 2615-2617Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.03.043
Keywords
Aspergilazine A; Diketopiperazine dimer; Aspergillus taichungensis; Antiviral activity
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Funding
- Chinese National Science Fund [30973627]
- Shandong Provincial Natural Science Fund [ZR2009CZ016]
- State Oceanic Administration [2010418022-3]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0944]
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A novel diketopiperazine (DKP) dimer, aspergilazine A (1), dimerized by two DKP units via a rare N-1 to C-6 linkage, was isolated from the marine-derived fungus Aspergillus taichungensis ZHN-7-07. The structure was determined by the combination of spectroscopic and Marfey's methods. Biological evaluation indicated that aspergilazine A (1) had a weak activity against influenza A (H1N1) virus. (C) 2012 Elsevier Ltd. All rights reserved.
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