4.4 Article

One-pot four-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives

Journal

TETRAHEDRON LETTERS
Volume 53, Issue 52, Pages 7075-7077

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.10.063

Keywords

Multicomponent reaction; Green synthesis; Phthalazine derivative; One-pot

Funding

  1. Select Project in Scientific and Technological Activities for Returned Scholars of Chongqing Personnel Bureau
  2. Doctoral Foundation of Southwest University [SWU112019]

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The synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives by NiCl2-catalyzed novel one-pot four-component condensation reaction of phthalimide, hydrazine, malononitrile (or ethyl cyanoacetate), and aromatic aldehydes was reported. This work provides a simple, efficient, and eco-friendly method for the construction of pyrazolo[1,2-b]phalazine-5,10-dione derivatives. (C) 2012 Elsevier Ltd. All rights reserved.

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