Journal
TETRAHEDRON LETTERS
Volume 53, Issue 7, Pages 871-875Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.12.027
Keywords
Sulfated tungstate; Strecker reaction; alpha-Aminonitriles; TMSCN
Categories
Funding
- University Grants Commission of India
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A straightforward, mild, efficient, and general method has been developed for the synthesis of alpha-aminonitriles via Strecker reaction starting from aldehydes or ketones, amines, and trimethylsilyl cyanide in the presence of sulfated tungstate as a heterogeneous mild solid acid catalyst at room temperature and solvent free condition. The developed method has been successfully applied for the synthesis of a wide range of alpha-aminonitriles with variable functionality. (C) 2011 Elsevier Ltd. All rights reserved.
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