4.4 Article

The stereoselective total synthesis of (3R,5R)-sonnerlactone and (3R,5S)-sonnerlactone

Journal

TETRAHEDRON LETTERS
Volume 53, Issue 47, Pages 6380-6382

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.09.032

Keywords

Sonnerlactones; Antiproliferative; Asymmetric allylation; Alder-Rickert reaction; Mitsunobu macrolactonization

Funding

  1. CSIR, New Delhi, India

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The stereoselective synthesis of (3R,5R)-sonnerlactone (1) and (3R,55)-sonnerlactone (2) has been accomplished starting from L-aspartic acid. Our strategy involves asymmetric allylation, Alder-Rickert reaction and Mitsunobu macrolactonization as the key steps. (C) 2012 Elsevier Ltd. All rights reserved.

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