Journal
TETRAHEDRON LETTERS
Volume 53, Issue 33, Pages 4381-4384Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.06.019
Keywords
Alkylation; Ketone; Olefin; Catalyst; Addition
Categories
Funding
- JSPS
- ERATO from JST
- Grants-in-Aid for Scientific Research [23890034] Funding Source: KAKEN
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alpha-Alkylation of ketones with styrene derivatives was developed using a mesitylcopper-dppp complex as a soft Bronsted base catalyst. No waste derived from the alkylating reagent was produced in this catalytic alkylation reaction. The bisphosphine ligand structure, as well as the reaction solvent, had profound effects on catalyst activity. The reaction proceeded under mild conditions from a range of ketones and styrene derivatives. The present catalysis is especially useful for the selective mono-alkylation of ketones. (c) 2012 Elsevier Ltd. All rights reserved.
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