Journal
TETRAHEDRON LETTERS
Volume 53, Issue 32, Pages 4228-4231Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.05.162
Keywords
Pentacyclic guanidine alkaloids; Monanchomycalins; Spermidine; Marine sponge; Monanchora pulchra
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Funding
- RF [NSS 546.2012.4]
- FEB RAS [12-III-A-05-060]
- RFBR [12-04-00749-a]
- Program of Presidium of RAS Molecular and Cell Biology
- Ministry of Land, Transport and Maritime Affairs, Republic of Korea [PM56641]
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New pentacyclic guanidine alkaloids, monanchomycalins A (1) and B (2) were isolated from the marine sponge, Monanchora pulchra and their structures elucidated using NMR, HRMALDI-TOF-MS, and HRESI MS, as well as by chemical transformations of 1. Compounds 1 and 2 exhibited potent cytotoxic activities against HL-60 human leukemia cells with IC50 values of 120 and 140 nM, respectively. (C) 2012 Elsevier Ltd. All rights reserved.
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