Journal
TETRAHEDRON LETTERS
Volume 53, Issue 39, Pages 5270-5274Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.07.079
Keywords
Multicomponent reaction; Indium triflate; Spiro-hexahydropyrimidines
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Funding
- Council for Scientific and Industrial Research (CSIR) New Delhi
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A mild, efficient, and expeditious method has been developed for the synthesis of spiro-hexahydropyrimidine derivatives via a three-component, one-pot cyclocondensation reaction of aromatic amines, formaldehyde, and cyclic ketones in 4-6 h using In(OTf)(3) as Lewis acid catalyst for the first time. The reaction involving creation of six new covalent bonds was efficiently promoted by 10 mol % In(OTf)(3) and the catalyst could be recovered easily after the reaction and reused without any loss of its catalytic activity. The advantageous features of this methodology are high atom-economy, operational simplicity, shorter reaction time, and easy handling. (c) 2012 Elsevier Ltd. All rights reserved.
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