Journal
TETRAHEDRON LETTERS
Volume 53, Issue 14, Pages 1699-1700Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.01.045
Keywords
Isatins; Triethyl phosphate; alpha(1)-oxindole-alpha-hydroxyphosphonates; Polyethylene glycol; Catalyst free conditions
Categories
Funding
- IICT
- UGC-BSR New Delhi
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A simple, efficient, eco-friendly, and cost-effective method has been developed for the synthesis of alpha(1)-oxindole-alpha-hydroxyphosphonate derivatives (3a-o) by a one-pot reaction of isatins (1a-o) with trialkyl phosphites (2a-o) under catalyst-free-conditions using inexpensive, non-toxic polyethylene glycol (PEG-400) in excellent yields (82-92%). The present methodology offers an environmental acceptability; low cost, high yields, and recyclability of the PEG-400 are the important features of this protocol. (C) 2012 Elsevier Ltd. All rights reserved.
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