Journal
TETRAHEDRON LETTERS
Volume 53, Issue 23, Pages 2885-2886Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.03.133
Keywords
Acremolin; A modified base; 1H-Azirine functionality; Marine fungus; Acremonium strictum
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Funding
- National Research Foundation of Korea (NRF)
- Korean government (MEST, Ministry of Education, Science and Technology) [20110030638, 20110018562]
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Acremolin (1), a novel modified base, was isolated from the culture broth of the marine fungus Acremonium strictum. Based on combined spectroscopic analyses, the structure of this compound was that of a methyl guanine base containing an isoprene unit. In addition, the presence of a 1H-azirine moiety is unprecedented among natural products. This compound exhibited weak cytotoxicity against an A549 cell line. (C) 2012 Elsevier Ltd. All rights reserved.
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