Journal
TETRAHEDRON LETTERS
Volume 53, Issue 25, Pages 3140-3143Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.04.033
Keywords
Multicomponent reaction; 3-Benzyl substituted coumarin derivative; Nano crystalline ZnO; Green synthesis
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Funding
- U.G.C.
- Calcutta University
- U.G.C, New Delhi, India
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A green, efficient and facile protocol was developed for the synthesis of a series of benzylamino coumarin derivatives by the reaction of 4-hydroxycoumarin, cyclic secondary amine, and aromatic aldehyde in aqueous media in the presence of nano crystalline ZnO at room temperature. A wide range of functional groups were tolerated in the developed protocol. The target molecules were obtained in good to excellent yield applying the current method. The nano crystalline ZnO can be recycled five times with almost the same catalytic activity. (C) 2012 Elsevier Ltd. All rights reserved.
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