4.4 Article

Studies toward the synthesis of spirolucidine. Preparation of ABC and EF ring fragments

Journal

TETRAHEDRON LETTERS
Volume 53, Issue 11, Pages 1347-1350

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.12.127

Keywords

Alkaloid synthesis; Lycopodium alkaloids; Nitrogen heterocycles; 1-Acylpyridinium salts; Asymmetric synthesis

Funding

  1. National Institutes of Health [GM 34442]
  2. North Carolina Biotechnology Center
  3. National Science Foundation [CHE-0078253]

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ABC and EF ring fragments of spirolucidine have been prepared via asymmetric synthesis using chiral N-acylpyridinium salt chemistry. Model studies have been carried out to support further progress toward the completion of this complex alkaloid. (C) 2012 Elsevier Ltd. All rights reserved.

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