Journal
TETRAHEDRON LETTERS
Volume 53, Issue 39, Pages 5197-5201Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.07.002
Keywords
Rhodanine; Microwave; Multicomponent reaction; Green chemistry; Cyclization
Categories
Funding
- Studienstiftung des deutschen Volkes
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Two aqueous, one-pot, microwave-assisted methods for the rapid synthesis of N-substituted rhodanines from amine substrates are described. Alkyl- and benzylamines could be converted into the corresponding rhodanines with an atom-efficient one-pot, three-step protocol based on carbon disulfide and chloroacetic acid in short reaction times and good to excellent yields. An alternative, microwave-assisted one-pot, one-step protocol using bis(carboxymethyl)trithiocarbonate in water was developed for the synthesis of N-arylrhodanines from anilines. (c) 2012 Elsevier Ltd. All rights reserved.
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