Journal
TETRAHEDRON LETTERS
Volume 53, Issue 2, Pages 151-156Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.10.154
Keywords
alpha-Aminonitriles; Zinc cyanide; Catalyst-free; Multicomponent; Eco-friendly
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Funding
- University Grant Commission (UGC) New Delhi
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An efficient and eco-friendly method has been developed for the synthesis of alpha-aminonitriles via one-pot three-component condensation of carbonyl compounds, amines, and Zn(CN)(2) under mild conditions. This protocol has the features of use of inexpensive, ecofriendly readily available, effective cyanide source, high yield, and simple work-up procedure. (C) 2011 Elsevier Ltd. All rights reserved.
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