Journal
TETRAHEDRON LETTERS
Volume 53, Issue 8, Pages 919-922Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.12.021
Keywords
Pycnoporus; Trypanosoma; Leishmania; Meroterpenoids; Coibanoles
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Funding
- US NIH [2 U01 TW006634-06]
- College of Agriculture and Life Sciences at the University of Arizona
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Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus Pycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites 'coibanoles A-C' in reference to Coiba Island and Coiba National Park, Panama, from which the plant and endophyte were collected. The extract was inactive to the human parasites Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum at a test concentration of 10 mu g/mL. (C) 2011 Elsevier Ltd. All rights reserved.
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