4.4 Article

Bispidine as a secondary structure nucleator in peptides

Journal

TETRAHEDRON LETTERS
Volume 53, Issue 6, Pages 623-626

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.11.112

Keywords

Bispidine; Secondary structure; Beta sheet; Beta turn; Peptide

Funding

  1. Department of Science and Technology (DST), New Delhi

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Here we describe bispidine as a scaffold for inducing open turn-like and beta sheet conformations on the attached peptides depending on the mode of attachment of peptides to the scaffold. Various bispidine-peptide conjugates were designed and synthesized to demonstrate the versatility of the scaffold. (C) 2011 Elsevier Ltd. All rights reserved.

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