Journal
TETRAHEDRON LETTERS
Volume 53, Issue 43, Pages 5759-5762Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.08.049
Keywords
Soft coral; Sinularia pavida; Pavidolides A-E; Structural elucidation; Antifouling activity; Cytotoxic activity
Categories
Funding
- NSFC [30930109]
- National Innovation Project [2009ZX09501-014, 2009ZX09103-140]
- CMST Projects [2010DFA31610]
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Five new cembrane-based diterpenoids, namely pavidolides A-E (1-5) were isolated from the marine soft coral Sinularia pavida, together with sarcophytin and chatancin. The structures of new compounds were determined on the basis of extensive spectroscopic data analysis. Pavidolide B (2) possesses an unprecedented 6,5,7-tricarbocyclic nucleus, whereas pavidolide C (3) is characteristic of an unusual C-5 and C-9 conjuncted cembranoid. Pavidolides C and D showed moderate antifouling activity against the larval settlement of barnacle Balanus amphitrite, while pavidolides B and C exhibited inhibitory activity against the human leukemia cell line HL-60. (C) 2012 Elsevier Ltd. All rights reserved.
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