Journal
TETRAHEDRON LETTERS
Volume 53, Issue 30, Pages 3937-3939Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.05.095
Keywords
Sinularia; Soft coral; Sulfur-containing compounds; Alkaloids; iNOS inhibition
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Funding
- European Community [REGPOT-2008-1-NatPharma]
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Chemical analysis of the Indonesian soft coral Sinularia sp. (order Alcyonacea, family Alcyoniidae) afforded two new alkaloids, named sinulasulfoxide (1) and sinulasulfone (2), characterized by an amide linkage between a phytanic acid moiety and an uncommon sulfur-containing unit. Their complete stereostructures were elucidated by interpretation of MS and NMR data along with CD analysis and chemical modifications. Sinulasulfoxide (1) proved to moderately inhibit LPS-induced NO release. (C) 2012 Elsevier Ltd. All rights reserved.
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