4.4 Article

Organocatalytic enantioselective substitution of MBH carbonates by 2-fluoromalonates

Journal

TETRAHEDRON LETTERS
Volume 53, Issue 32, Pages 4124-4129

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.05.121

Keywords

Organocatalysis; MBH carbonates; Lewis base; Fluorine; Enantioselective

Funding

  1. Spanish Ministry of Science and Innovation (MICINN) [AYA2009-13920-C02-02]
  2. China Scholarship Council
  3. MICINN
  4. ICREA Funding Source: Custom

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The enantioselective fluoromalonate addition to Morita-Baylis-Hillman carbonates is presented. The reaction is simply catalyzed by beta-isocupreidine affording the final fluorinated products in good yields and enantioselectivities. (C) 2012 Elsevier Ltd. All rights reserved.

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