Journal
TETRAHEDRON LETTERS
Volume 53, Issue 3, Pages 325-328Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.11.038
Keywords
Sorbicillinoid; Marine derived fungus; Penicillium terrestre
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Funding
- Chinese National Science Fund [30973627, 41176120]
- Shandong Provincial Natural Science Fund [ZR2009CZ016]
- Promotive research fund for excellent young and middle-aged scientists of Shandong Province [BS2010HZ027]
- specialized research fund for the doctoral program of higher education [20100132120026]
- State Oceanic Administration [2010418022-3]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0944]
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A novel sorbicillinoid named sorbiterrin A (1), possessing an unprecedented skeleton was isolated from a marine sediment derived fungus Penicillium terrestre. The structure including absolute stereochemistries was elucidated by analysis of NMR, MS data and TDDFT CD calculations. Sorbiterrin A showed moderate acetylcholinesterase (AChE) inhibitory effect with IC50 25 mu g/mL. (C) 2011 Elsevier Ltd. All rights reserved.
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