Nano indium oxide catalyzed efficient synthesis of propargylamines via C-H and C-Cl bond activations

A simple, and efficient nano In2O3 catalyzed one-pot three-component coupling of terminal alkyne, dichloromethane. and secondary amine has been developed for the synthesis of propargylamines under mild reaction conditions. The catalyst was recovered and reused for three times without significant loss of catalytic activity. (C) 2011 Elsevier Ltd. All rights reserved.