4.4 Article

Negishi cross-coupling of organotellurium compounds: synthesis of biaryls, aryl-, and diaryl acetylenes

Journal

TETRAHEDRON LETTERS
Volume 52, Issue 34, Pages 4398-4401

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.06.025

Keywords

Tellurium; Diaryl tellurides; Zinc; Negishi reaction; Aromatic rings

Funding

  1. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [300.613/2007-5]
  2. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [07/59404-2, 10/15677-8]
  3. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [10/15677-8] Funding Source: FAPESP

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A functional group tolerant palladium-catalyzed Negishi coupling of diaryl tellurides with organozinc has been developed. This methodology permits efficient preparation of biaryls, aryl acetylenes and diaryl acetylenes in moderate to good yields. A preliminary study to gain further insight into the reaction was performed using in situ ReactIR technology. (C) 2011 Elsevier Ltd. All rights reserved.

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