4.4 Article

Efficient one-pot synthesis of functionalized piperidine scaffolds via ZrOCl2•8H2O catalyzed tandem reactions of aromatic aldehydes with amines and acetoacetic esters

Journal

TETRAHEDRON LETTERS
Volume 52, Issue 22, Pages 2857-2861

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.03.116

Keywords

ZrOCl2 center dot 8H(2)O; One-pot synthesis; Functionalized piperidine; Tandem reaction

Funding

  1. UGC, India

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A highly efficient diastereoselective one-pot synthesis of functionalized piperidines has been developed based on an aqua-compatible ZrOCl2 center dot 8H(2)O catalyst via tandem reactions of aromatic aldehydes, amines, and acetoacetic esters. (C) 2011 Elsevier Ltd. All rights reserved.

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