4.4 Article

Concise total syntheses of (±)isopaucifloral F, (±)quadrangularin A, and (±)pallidol

Journal

TETRAHEDRON LETTERS
Volume 52, Issue 22, Pages 2815-2817

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.03.002

Keywords

Natural products; Pallidol; Quadrangularin A; Isopaucifloral F; Total syntheses

Funding

  1. National Drug Innovative Program [2009ZX09301-011]
  2. National Natural Science Foundation of China [30973612]
  3. Shanghai Municipal Committee of Science and Technology [08JC1401600]

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Concise total syntheses of (+/-)isopaucifloral F. (+/-)quadrangularin A, and (+/-)pallidol, starting from commercially available 3,5-dimethoxybenzoic acid, have been achieved by a sequential process. The overall synthetic strategy involves Nazarov cyclization, Ramberg-Backlund olefination, and Friedel-Crafts alkylation. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

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