4.4 Article

A de novo Diels-Alder strategy toward the novel pentacyclic natural product fluostatin C: a concise synthesis of 6-deoxyfluostatin C

Journal

TETRAHEDRON LETTERS
Volume 52, Issue 27, Pages 3505-3508

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.04.113

Keywords

Natural product synthesis; Cytostatic agents; Diels-Alder reaction; Regioselectivity; Aromatization

Funding

  1. CSIR
  2. Government of India

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A conceptually new Diels-Alder approach, involving a diene moiety grafted on a preformed epoxyquinone platform and a 4-hydroxy-indenone as the dienophile, delivers the pentacyclic framework of fluostatin C in one key step. (C) 2011 Elsevier Ltd. All rights reserved.

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