Synthesis of a series of monomeric styrene sulfobetaine precursors

Procedures for the synthesis of five sulfobetaine monomers as styrene derivatives are given. The five molecules form a homologous row differing in the distance between the inner quaternary amine and the outer sulfonic acid from one methylene group to five methylene groups. Syntheses are achieved by a sequence of nucleophilic substitutions starting from commercially available precursors. (C) 2011 Elsevier Ltd. All rights reserved.