Journal
TETRAHEDRON LETTERS
Volume 52, Issue 12, Pages 1273-1276Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.01.025
Keywords
Premna latifolia; Icetexane diterpenes; Cytotoxic activity; Cancer cell lines
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Funding
- CSIR
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Chromatographic fractionation of a hexane extract from stem-bark of Premna latifolia yielded three new icetexane diterpenes (1-3). Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS, data. Compounds 1-3 were also evaluated for the cytotoxicity against the cancer cell lines (HT-29, A-431, MCF-7, Hep-G2, PC-3, A-549, B-16 F10 and ACHN). Compounds 1 and 2 displayed potent cytotoxic activity against HT-29 and Hep-G2 cell lines with IC50 values of 0.04 and 0.18 mu g/mL, respectively. (C) 2011 Elsevier Ltd. All rights reserved.
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