Journal
TETRAHEDRON LETTERS
Volume 52, Issue 48, Pages 6508-6511Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.09.119
Keywords
Multi-component reactions; Spiro dihydropyridines; Monoketones; Diketones; Activated alkynes
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Funding
- Council of Scientific and Industrial Research (CSIR), New Delhi, India
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An efficient preparation of a series of Spiro dihydropyridines via one pot four-component reactions of mono/di/tri-ketones, malononitrile, primary amines, and acetylenic esters is reported. The reaction is atom-efficient, high yielding, and follows a simple experimental procedure. (C) 2011 Elsevier Ltd. All rights reserved.
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