Journal
TETRAHEDRON LETTERS
Volume 52, Issue 12, Pages 1265-1268Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.01.017
Keywords
Aldehydes; 2,3-Dihydropyridines; Indium triflate; Ketones; Malononitrile; Multi-component reaction
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A convenient and efficient one-pot multi-component synthesis of novel polysubstituted 4-amino-2,3-dihydropyridines from carbonyl compounds, malononitrile and acetonitrile, using indium triflate is reported. Acetonitrile acts both as a solvent as well as a substrate. (C) 2011 Elsevier Ltd. All rights reserved.
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