Journal
TETRAHEDRON LETTERS
Volume 52, Issue 3, Pages 373-376Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.11.028
Keywords
Cyclization; Coumarins; Anilines; Heterocycles; Fluorine; Chromeno[4,3-b]quinolines
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Funding
- State of Mecklenburg-Vorpommern
- European Regional Development Fund (EFRE)
- State of Pakistan
- German Ministry of Education and Research (BMBF) [03IS2081A]
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4-Chloro-3-(trifluoroacetyl)coumarin was synthesized for the first time via direct TMSCl-mediated acylation of 4-hydroxycoumarin with TFAA followed by the treatment with POCl3. The reaction of 4-chloro-3-(trifluoroacetyl)coumarin with commercially available anilines is a two-step method, which affords a set of 7-(trifluoromethyl)-6H-chromeno[4,3-b]quinolin-6-ones in good to excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.
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