Journal
TETRAHEDRON LETTERS
Volume 52, Issue 21, Pages 2676-2678Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.03.073
Keywords
Marine sponge; Cymbastela cantharella; Pyrrole-2 aminoimidazole; Dihydrohymenialdisine
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In our investigation of bioactive marine natural products, we revisited an ethanolic extract of the New Caledonian sponge Cymbastela cantharella. Four new natural compounds (3-6) were isolated and their structural determinations as dihydrohymenialdisine derivatives were achieved by spectral data analysis and chemical conversion. These products did not show any activity in the Polo Like kinase bioassay, demonstrating thus the importance of the unique structure of hymenialdisine, known as an improved kinase inhibitor. (C) 2011 Elsevier Ltd. All rights reserved.
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