4.4 Article

Convenient synthesis of fluorazone derivatives by one-pot pyrrolation/cyclization of anthranilic acids

Journal

TETRAHEDRON LETTERS
Volume 52, Issue 44, Pages 5824-5826

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.08.139

Keywords

4-Chloropyridine hydrochloride; Clauson-Kaas pyrrolation; Ring closure reaction; Fused pyrrole derivatives

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A series of fused heterocyclic compounds based on a fluorazone structure has been prepared from anthranilic or ortho-aminoheteroaryl carboxylic acids by one-pot sequential pyrrolation/cyclization catalyzed by 4-chloropyridine hydrochloride, in generally good yield. (C) 2011 Elsevier Ltd. All rights reserved.

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