Journal
TETRAHEDRON LETTERS
Volume 52, Issue 47, Pages 6295-6297Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.09.094
Keywords
Multicomponent reaction; Ugi-reaction; 1,6-Enyne; Pd-II/IV-catalysis; Cycloaddition
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A variety of 1,6-enynes were synthesized by an Ugi-reaction and further elaborated by a Pd-II/IV catalyzed oxidative cyclization to produce N-substituted 3-aza-bicyclo[3.1.0]hexan-2-ones. Different substitution patterns were tested to examine the scope and limitations of the amide tethered substrates. (C) 2011 Elsevier Ltd. All rights reserved.
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