Journal
TETRAHEDRON LETTERS
Volume 52, Issue 43, Pages 5672-5675Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.08.100
Keywords
FTY720; Immunosuppressant; Multiple sclerosis; Wittig reaction; Aqueous chemistry
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Funding
- NSERC
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A short, convergent synthesis of the immunosuppressant FTY720 is described involving the use of 4-hydroxymethylbenzaldehyde as a pivotal intermediate. A double Wittig strategy was developed to connect this dual-functional aldehyde with an alkyl-tether and to a readily available TRIS-derivative leading to an efficient synthesis of the target molecule. (C) 2011 Elsevier Ltd. All rights reserved,
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