Journal
TETRAHEDRON LETTERS
Volume 52, Issue 32, Pages 4218-4220Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.06.026
Keywords
Non-steroidal anti-inflammatory drugs; Ibuprofenamide; Nitrile hydration; Microwave irradiation; Ruthenium
Categories
Funding
- Spanish MICINN [CTQ2006-08485/BQU, CTQ2010-14796/BQU, CSD2007-00006]
- MEC of Spain
- European Social Fund (FPU program)
Ask authors/readers for more resources
An efficient and practical synthesis of the non-steroidal anti-inflammatory drug (NSAID) ibuprofenamide by catalytic hydration of 2-(4-isobutylphenyl)propionitrile is described. The readily accessible areneruthenium(II) complex [RuCl2(eta(6)-C6Me6){P(NMe2)(3)}] is used as the catalyst, pure water as the solvent, and microwave irradiation as the heating source. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
