Clausenawallines A and B, two new dimeric carbazole alkaloids from the roots of Clausena wallichii

Two new dimeric carbazole alkaloids, clausenawallines A and B, were isolated from the roots of Clausena wallichii. Their structures were elucidated by spectroscopic methods. Clausenawalline A was evaluated for its biological activities [anti-malaria (IC50 2.46 mu g/mL), anti-TB (MIC 12.50 mu g/mL)] and cytotoxicity against three human cancer cell lines [KB (IC50 7.87 mu g/mL), MCF7 (IC50 25.43 mu g/mL), and NCI-H187 (IC50 10.97 mu g/mL)]. (C) 2011 Elsevier Ltd. All rights reserved.