Journal
TETRAHEDRON LETTERS
Volume 52, Issue 16, Pages 1987-1989Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.02.078
Keywords
Aspergillus versicolor; Biosynthesis; Prenylated indole alkaloid
Categories
Funding
- National Institutes of Health [CA70375]
- Naito Foundation
- Grants-in-Aid for Scientific Research [22406001, 22310138] Funding Source: KAKEN
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Notoamide E, a short-lived secondary metabolite, has been proposed as a biosynthetic intermediate to several advanced metabolites isolated from Aspergillus versicolor. In order to verify the role of this indole alkaloid along the biosynthetic pathway, synthetic doubly C-13-labeled notoamide E was fed to Aspergillus versicolor. Analysis of the metabolites showed significant incorporation of notoamide E into the natural products notoamides C and D. (C) 2011 Elsevier Ltd. All rights reserved.
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