Journal
TETRAHEDRON LETTERS
Volume 52, Issue 16, Pages 1898-1900Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.02.038
Keywords
C-H functionalization; Copper-catalyzed; Fluorination; Oxidative coupling; Heterocycle
Categories
Funding
- Canada Research Chair (Tier I) foundation
- NSERC
- FRQNT
- McGill University
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Copper-catalyzed trifluoromethylation via oxidative sp(3) C-H activation at the alpha-position of nitrogen in tetrahydroisoguinoline derivatives using DDQ and Ruppert-Prakash reagent has been successfully achieved. The reaction of various amines gave the corresponding trifluoromethylated products in 15-90% yields under mild conditions. (C) 2011 Elsevier Ltd. All rights reserved.
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