Journal
TETRAHEDRON LETTERS
Volume 52, Issue 18, Pages 2404-2406Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.02.110
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology in Japan [20550033]
- Chiba University
- Japan Chemical Innovation Institute (JCII)
- Futaba Electronics Memorial Foundation
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Various aromatic bromides were efficiently transformed into the corresponding aromatic nitriles in good yields via the formations of Grignard reagents and subsequently N,N-dimethyl formamide (DMF) adducts, followed by treatment with molecular iodine (I-2) in aq NH3 at room temperature. The present reaction is an easy and practical method for the preparation of aromatic nitriles from aromatic bromides with less toxic reagents, such as Mg, DMF, I-2, and aq NH3. (C) 2011 Elsevier Ltd. All rights reserved.
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