Journal
TETRAHEDRON LETTERS
Volume 52, Issue 11, Pages 1217-1221Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.01.039
Keywords
PTP inhibitors; Direct alpha-halogenation; Chlorotrimethylsilane; Nitryl chloride; Density functional theory
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Funding
- Loker Hydrocarbon Research Institute
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A mixture of chloro/bromotrimethylsilane and nitrate salt is found to be an effective reagent system for the alpha-chlorination/bromination of carbonyl compounds. The reaction occurs under mild conditions yielding the products in moderate to good yields. (C) 2011 Elsevier Ltd. All rights reserved.
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