Journal
TETRAHEDRON LETTERS
Volume 52, Issue 17, Pages 2136-2139Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.11.165
Keywords
Ustiloxin; Tubulin polymerization; Aziridine ring opening; Structure-activity relationships
Categories
Funding
- NIH [CA-40081, 1S10RR23444-1]
- NSF [CHE-0951394]
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Four novel ustiloxin D analogues were synthesized focusing on the size of the macrocyclic core, the stereochemistry at the bridgehead ether, and the enantiomer of ustiloxin D. All four were subjected to biological evaluation testing the inhibition of tubulin polymerization. Only 2,2-dimethyl-ustiloxin D retained any activity. (C) 2011 Elsevier Ltd. All rights reserved.
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