Journal
TETRAHEDRON LETTERS
Volume 52, Issue 8, Pages 903-906Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.12.060
Keywords
Oxindole; Mannich reaction; Formalin; Aminomethylation; Water mediated reaction
Categories
Funding
- National Natural Science Foundation of China [20802074]
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A simple and eco-friendly method for the aminomethylation of various 3-substituted oxindoles via three-component Mannich reaction in aqueous media has been established. A variety of oxindoles containing a quaternary carbon center, which comprises an aminomethyl group were obtained smoothly in good yields (up to 93%) with this method. Particularly valuable features, such as employing cheap and readily available formalin as a useful aminomethylation Cl unit and using water as a reaction medium, are embodied in this method. (C) 2010 Elsevier Ltd. All rights reserved.
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