Journal
TETRAHEDRON LETTERS
Volume 52, Issue 10, Pages 1074-1077Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.12.090
Keywords
Beckmann rearrangement; Propylphosphonic anhydride; Ketoximes; Acetanilides; Nitriles
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An efficient method for the Beckmann rearrangement of ketoximes to amides mediated by a catalytic amount (15 mol %) of propylphosphonic anhydride (T3P1 (R)) is described. Aldoximes underwent second order Beckmann rearrangement to provide the corresponding nitriles in excellent yields on reacting with T3P (15 mol %) at room temperature. The main advantages of this environmentally friendly protocol include procedural simplicity, and particularly ease of isolation of the products. (C) 2010 Elsevier Ltd. All rights reserved.
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