Journal
TETRAHEDRON LETTERS
Volume 52, Issue 1, Pages 101-106Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2010.10.172
Keywords
Cyclic voltammetry; Indole derivatives; Scavenging activity; Reactive oxygen species; Melatonin
Categories
Funding
- FCT [PTDC/QUI/65187/2006, SFRH/BD/46234/2008]
- Fundação para a Ciência e a Tecnologia [PTDC/QUI/65187/2006, SFRH/BD/46234/2008] Funding Source: FCT
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The electrochemical behavior of an indole library of compounds, including several tryptophan and tryptamine derivatives previously demonstrated to be active against several reactive oxygen species (ROS), was investigated. For this purpose, a voltammetry study was undertaken and the oxidation potential was correlated to the scavenging activity reported for the studied indoles. All the compounds showed an oxidation potential peak lower than that observed for indole (Epox = 1.035 V), but higher than that described for the antioxidant melatonin (Epox = 0.715 V). The electrochemical behavior showed a high correlation with the scavenging activity of peroxyl radical, for selected compounds. (C) 2010 Elsevier Ltd. All rights reserved.
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